樊智文，南京大学，南京大学医学院附属鼓楼医院，助理研究员
主要从事分子病理相关的临床检测与研究工作。研究方向是肝脏疾病相关转录事件的调控机制研究。

1 科研项目

目前主持国家自然科学基金青年项目，南京市医学科技发展一般项目，教育部中央高校培育项目共3项，参与国家自然科学基金面上项目2项。发表SCI论文14篇，分别发表在《Hepatology》、《J Hepatol》、《Arterioscler Thromb Vasc Biol》、《BBA-Gene Regul Mech》等。其中第一作者（含并一）9篇，最高影响因子14.079。

2 近三年发表的相关论文
Fan ZW^#, Li Z^#, Yang Y^#, Liu S, Guo J, Xu Y^*: TheHIF-1a coordinates epigenetic activation of SIAH1 in hepatocytes in response to nutritional stress. Biochim Biophys Acta. 2017 Aug 23[Epub ahead of print]
Fan ZW^#, Li LY^#, Li M^#, Zhang XJ, Yu LM, Hao CZ, Zeng S, Xu HH, Fang MM, Shen AG^*, Jenuwein T, Xu Y^*: The histone methyltransferase Suv39h2 contributes to non-alcoholic steatohepatitis in mice. Hepatology. 2017 Jun; 65(6): 1904-191
Fan ZW, Li JF, Li P, Ye Q, Xu HH, Wu XY, Xu Y^*: PRMT1 represses MHC II transcription in macrophages by methylating CIITA. Sci Rep. 2017 Jan 17;7:4053
Sun L^#, Fan Z^#, Chen J^#, Tian W, Li M, Xu H, Wu X, Fang M, Xia J^*, Xu Y^*: Protein inhibitor of activated STAT 4 (PIAS4) regulates pro-inflammatory transcription in hepatocyte by repressing SIRT1. Oncotarget. 2016 Jul 12;7(28):42892-42903
Sun LN^#, Fan ZW^#, Chen JL^#, Tian WF, Li M, Xu HH, Wu XY, Shao J, Bian YY^*, Fang MM, Xu Y^*: Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis. Sci Rep. 2016 Jun 21;6:28432.
Fan ZW^#, Kong XC^#, Xia J^#, Wu XY^#, Li H, Xu HH, Fang MM, Xu Y^*: The arginine methyltransferase PRMT5 regulates CIITA-dependent MHC II transcription. BBA-Gene Regul Mech. 2016 May 2; 1859(5): 687-96.
Fan ZW, Hao CZ, Li M, Dai X, Qin H, Li JF, Xu HH, Wu XY, Zhang LP, Fang MM, Zhou BS, Tian WF, Xu Y^*: MKL1 is an epigenetic modulator of TGF-b induced fibrogenesis. BBA-Gene Regul Mech. 2015 Aug 14; 1849(8): 1219-28.
Fang M^#, Fan Z^#, Tian W^#, Zhao Y, Li P, Xu H, Zhou B, Zhang L, Wu X^*, Xu Y^*: HDAC4 mediates IFN-g induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells. BBA-Gene Regul Mech. 2016 Feb 2; 1859(2): 294-305.
Tian W, Hao C, Fan Z^#, Weng X^#,Qin H, Wu X, Fang M, Chen Q, Shen A^*, Xu Y^*: Myocardin related transcription factor A programs epigenetic activation of hepatic stellate cells. J Hepatol. 2015 Jan; 62(1):165-74.
Yu L^#, Yang G^#, Weng X^#, Liang P, Li L, Li J, Fan Z, Tian W, Wu X, Xu H, Fang M, Ji Y, Li Y, Chen Q, Xu Y^*: Histone Methyltransferase SET1 Mediates Angiotensin II-Induced Endothelin-1 Transcription and Cardiac Hypertrophy in Mice. Arterioscler Thromb Vasc Biol. 2015 May;35(5):1207-17.
Cheng X^#, Yang Y^#, Fan Z, Yu L, Bai H, Zhou B, Wu X, Xu H, Fang M^*, Shen A, Chen Q, Xu Y^*: MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription. Oncogene. 2015 Oct 29; 34(44): 5570-81.
Tian WF, Fan ZW, Li JF, Hao CZ, Li M, Xu HH, Wu XY, Zhou BS, Zhang LP, Fang MM, Xu Y^*: Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling. Int J Biochem Cell Biol. 2016 Feb; 71(2):35-43.
Zhou B, Zeng S, Li L, Fan Z, Tian W, Li M, Xu H, Wu X, Fang M, Xu Y^*: Angiogenic factor with G patch and FHA domains 1 (Aggf1) regulates liver fibrosis by modulating TGF-b signaling. BBA-Mol Basis Dis. 2016 Jun; 1862(6): 1203-13.